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The disease was coincided with the presentation of a new total mixed ration to animals. The purpose of this paper is to present a description of Clostridium perfringens type A in calves that died suddenly with severe intra–luminal hemorrhage in the jejunum and abomasal ulcerations.Ī total of 8 calves aged between 8 to 11 month suffering from colic, and dark clotted blood in the faeces (melena) proceeded with death was admitted to the Veterinary Teaching Hospital of the college of Veterinary Medicine and Animal resources, king Faisal, Saudi Arabia. perfringens toxins detection ( Francisco and Glenn, 2008). ELISAs are considered one of the most important laboratory technique for C. Detection of toxins in intestine is very important to establish a diagnosis. History, clinical signs, and gross postmortem findings are useful in establishing a presumptive diagnosis of clostridial enterotoxemia, but confirmation requires laboratory testing. perfringens type A is also commonly isolated in calves in cases where abomasal ulcers and abomasal haemorrhage are found ( Roeder et al., 1987). perfringens type A produce β2–toxin which may contribute, along with α–toxin, to the development of hemorrhagic enteritis in cattle ( Jelinski et al., 1995 Bueschel et al., 2003 Abutarbush and Radostits, 2005). Alpha toxin is thought to be associated with a number of potentially deadly gastrointestinal diseases ( Hatheway, 1990).
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perfringens type A can rapidly produce potent toxins, primarily alpha toxin. However, dietary changes or parasitism may produce a favorable growth environment, resulting in overgrowth and production of potent toxins. It is part of the normal gut flora in cattle. perfringens (A, B, C, D, E), which are identified by the main types of toxins they produce (alpha, beta, iota, epsilon and theta) ( Niilo, 1987 Songer, 1996). perfringens infections in animals and man called enterotoxemias. Clostridium perfringens causes food poisoning and fatal enterotoxemia ( Yamagishi, 1997 Yoo, 1997).